Prognostic factors of choroidal melanoma in Slovenia, 1986–2008
نویسندگان
چکیده
INTRODUCTION Choroidal melanoma is the most common primary malignancy of the eye, which frequently metastasizes. The Cancer Registry of Slovenia reported the incidence of choroid melanoma from 1983 to 2009 as stable, at 7.8 cases/million for men and 7.4/million for women. The aim of the retrospective study was to determinate the prognostic factors of survival for choroidal melanoma patients in Slovenia. PATIENTS AND METHODS From January 1986 to December 2008 we treated 288 patients with malignant choroidal melanoma; 127 patients were treated by brachytherapy with beta rays emitting ruthenium-106 applicators; 161 patients were treated by enucleation. RESULTS Patients with tumours thickness < 7.2 mm and base diameter < 16 mm were treated by brachytherapy and had 5- and 10-year overall mortality 13% and 32%, respectively. In enucleated patients, 5- and 10-year mortality was higher, 46% and 69%, respectively, because their tumours were larger. Thirty patients treated by brachytherapy developed local recurrence. Twenty five of 127 patients treated by brachytherapy and 86 of 161 enucleated patients developed distant metastases. Patients of age ≥ 60 years had significantly lower survival in both treatment modalities. For patients treated by brachytherapy the diameter of the tumour base and treatment time were independent prognostic factors for overall survival, for patients treated by enucleation age and histological type of tumour were independent prognosticators. In first few years after either of treatments, the melanoma specific annual mortality rate increased, especially in older patients, and then slowly decreased. CONCLUSIONS It seems that particularly younger patients with early tumours can be cured, whereby preference should be given to eyesight preserving brachytherapy over enucleation.
منابع مشابه
Choroidal and Retinal Tumors in Adults: Choroidal Melanocytic Lesions
CHOROIDAL NEVUS Choroidal nevus (Figure 1), the most common primary intraocular tumor,1 is a benign tumor that arises from melanocytic cells derived from the neural crest. Choroidal nevi are more common in white people, with 4% of the population having at least one.1 Malignant transformation into melanoma is possible; therefore, choroidal nevi should be monitored even though the rate is 1 in 4,...
متن کاملProgression of Cutaneous Vitiligo in a Patient with Large Posterior Choroidal Melanoma: A Case Report.
BACKGROUND/AIMS The aim of our study was to report a case of progression of cutaneous vitiligo after large posterior choroidal melanoma diagnosis. METHODS The clinical history, fundus findings and histopathological features suggest the diagnosis of cutaneous vitiligous progression after a diagnosis of large posterior choroidal melanoma. RESULTS A 30-year-old female, with a personal history ...
متن کاملConcomitant primary breast carcinoma and primary choroidal melanoma: a case report
INTRODUCTION Choroidal melanoma and choroidal metastasis are distinct pathological entities with very different treatments and prognoses. They may be difficult to distinguish to the untrained observer. CASE PRESENTATION A case of concomitant choroidal melanoma in a woman with primary breast carcinoma is described. The choroidal lesion was thought initially to be a metastasis, and treated with...
متن کاملDifferential expression of the retinoblastoma gene family members in choroidal melanoma: prognostic significance.
We evaluated 55 samples of choroidal melanoma managed by enucleation. Knowing that the immunohistochemical expression of the retinoblastoma gene family members Rb/p105, p107, and pRb2/p130 was inversely correlated with the degree of malignancy in at least some histological types, we investigated the expression of these three proteins in choroidal melanoma. We focused on the relationship between...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 50 شماره
صفحات -
تاریخ انتشار 2016